反应详情

To 5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-1H-benzimidazole (460.5 mg) in DMF (5 mL) was added sodium hydride (103 mg of 60% in oil dispersion). The resulting mixture was stirred at room temperature for 5 min. To the dark green solution was added 1-(1-benzofuran-2-yl)-2-bromoethan-1-one (633 mg) and the resulting mixture was stirred at room temperature overnight. The reaction mixture was quenched with water, extracted with EtOAc, and dried over Na2SO4. The crude product was purified by silica gel chromatography (10%-40% EtOAc/hexanes) to yield the title compound as a yellow solid.

1. stirringthe resulting mixture was stirred at room temperature overnight
2. customThe reaction mixture was quenched with water
3. extractionextracted with EtOAc
4. dry with materialdried over Na2SO4
5. customThe crude product was purified by silica gel chromatography (10%-40% EtOAc/hexanes)