反应详情

To 5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-1H-benzimidazole (622 mg) in DMF (7 mL) was added potassium carbonate powder (958 mg) and 2,4-bis(trifluoromethyl)-benzyl bromide (2.13 g). The resulting mixture was stirred at room temperature overnight. The reaction mixture was quenched with water, extracted with EtOAc, and dried over Na2SO4. The crude product was purified by silica gel chromatography (5%-40% EtOAc/hexanes), followed by recrystallization with hexanes to yield the title compound as an orange solid.

1. customThe reaction mixture was quenched with water
2. extractionextracted with EtOAc
3. dry with materialdried over Na2SO4
4. customThe crude product was purified by silica gel chromatography (5%-40% EtOAc/hexanes)
5. customfollowed by recrystallization with hexanes