Allyl glycidyl ether → HCID 131723438, compound

HRID 2304355Notes

Reaction equation

HRID 2304355 reaction equation
Cl.[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].[OH-].[Na+].[CH2:14]([O:18][CH2:19][CH:20]=[CH2:21])[CH:15]1[O:17][CH2:16]1>>[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].[CH2:14]([O:18][CH2:19][CH:20]=[CH2:21])[CH:15]1[O:17][CH2:16]1

Participants

4

Reactant 3

HCID 7838Allyl glycidyl etherHCID 14798Sodium HydroxideHCID 69568L-Lysine monohydrochloride

Product 1

HCID 131723438HCID 131723438, compoundYield 62.5%

Procedure

10.0 g (54.7 mmol) of lysine monohydrochloride and a 31.8% NaOH solution (5.0 g of deionized water/8.75 g 50% NaOH) are placed into a round-bottomed flask equipped with a stirrer, nitrogen inlet and a thermoregulator. This mixture is heated with stirring. When a temperature of 650° C. is reached, 6.25 g (54.7 mmol) allyl glycidyl ether (AGE) is added over a one hour period. The reaction mixture is then stirred for two hours at 65° C., after which time the reaction is complete as determined by gas chromatography. This product is obtained as a clear yellow solution of 62.5% solids by weight.

Workup

  1. customequipped with a stirrer, nitrogen inlet
  2. temperatureThis mixture is heated
  3. customa temperature of 650° C.
  4. stirringThe reaction mixture is then stirred for two hours at 65° C.

Sources & evidence

ORD record
ord-d81275703e3549b28ca2fdb7e4bc2bab
Source dataset
uspto-grants-2002_08
Patent number
US06436306B1

Reaction notes

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