Anisole → 4'-Methoxyacetophenone

HRID 2304376Notes

Reaction equation

[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[CH3:8][O:7][C:1]1[CH:6]=[CH:5][C:4]([C:9](=[O:11])[CH3:10])=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 7519Anisole

HCID 7918Acetic Anhydride

Product 1

HCID 74764'-Methoxyacetophenone

Procedure

The reaction between anisole and acetic anhydride was performed in substantially the same manner as in Example 49, except that each of the compounds as synthesized in Examples 42 and 43 was individually used as the Lewis acid catalyst. The yields of the reaction product (i.e., p-methoxyacetophenone) are shown in Table 2.

Workup

customexcept that each of the compounds as synthesized in Examples 42 and 43

Sources & evidence

ORD record: ord-99d38ccd5c814c2a99a634c7902ca636
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06436866B1

Reaction notes

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