Hydrochloric Acid → HCID 18435644, compound

HRID 2304462Notes

Reaction equation

HRID 2304462 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1/[CH:13]=[CH:14]/[C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1.[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25].Cl>>[CH2:24]([N:26]([CH2:27][CH3:28])[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1/[CH:13]=[CH:14]/[C:15]1[O:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1)[CH3:25]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8021DiethylamineHCID 18435640HCID 18435640, compound

Product 1

HCID 18435644HCID 18435644, compoundYield 12%

Procedure

The procedure of Example 5 was followed starting with (D) of Example 5 (2.5 g, 7.6 mmol) and using diethylamine in place of dibutylamine to produce 0.32 g (12% yield) of the named compound as the HCl salt, mp 219°-220° C. IR(KBr): 3400, 1600 cm−1. MS: 365(MH+). 1H NMR (CDCl3): δ 8.25-6.82 (m, 10H), 4.02 (t, J=5.4 Hz, 2H), 3.14 (m, 6H), 1.99 (m, 4H), 1.36 (m, 6H).

Sources & evidence

ORD record
ord-8792eaa1aa004c55bfc4efd030d96339
Source dataset
uspto-grants-2002_08
Patent number
US06436939B2

Reaction notes

Loading…