Isopropanol → (7s, 8r, 9r)-2,3-Dimethyl-8-hydroxy-9-phenyl-7-(2-propoxy)-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]-naphthyridine

HRID 2304478Notes

Reaction equation

[CH3:1][C:2]1[N:3]=[C:4]2[C:13]3[NH:12][CH:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:10]([OH:20])[CH:9]([OH:21])[C:8]=3[CH:7]=[CH:6][N:5]2[C:22]=1[CH3:23].[CH3:24][CH:25](O)[CH3:26]>>[CH3:1][C:2]1[N:3]=[C:4]2[C:13]3[NH:12][C@H:11]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[C@@H:10]([OH:20])[C@@H:9]([O:21][CH:25]([CH3:26])[CH3:24])[C:8]=3[CH:7]=[CH:6][N:5]2[C:22]=1[CH3:23]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 21873957HCID 21873957, compound

Product 1

HCID 66952632(7s, 8r, 9r)-2,3-Dimethyl-8-hydroxy-9-phenyl-7-(2-propoxy)-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]-naphthyridine

Procedure

1 g of the title compound of melting point 168-9° C. is obtained by reaction of 3 g of 7R, 8R, 9R)-2,3-dimethyl-7,8-dihydroxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine with 2-propanol according to Example 1, Method a.

Sources & evidence

ORD record: ord-bfe2f5f7e83041bfb88b4cd287c8f79b
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06436953B1

Reaction notes

Loading…