反应详情

The compound obtained in Example 15 (1.8 g) was admixed with N-bromosuccinimide (0.88 g), azobisisobutyronitrile (70 mg) and ethyl acetate (18 ml) and the mixture was heated under reflux for 2 hours. At the time when about 1 hour and 30 minutes had elapsed during this procedure, the suspension turned into a solution. The suspension obtained after allowing to cool was cooled on ice, and the precipitated crystal was recovered by a filtration, washed with cool ethyl acetate and water to obtain the title compound (1.68 g, 79.1%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hours
3. customAt the time when about 1 hour and 30 minutes
4. customThe suspension obtained
5. temperatureto cool
6. temperaturewas cooled on ice
7. filtrationthe precipitated crystal was recovered by a filtration
8. washwashed with cool ethyl acetate and water