Acetic Acid → HCID 178497377, compound

Temperature

80 °C

In a 350 ml steel autoclave with teflon insert was placed 1H-benzimidazole-5-carboxylic acid (10 g, 61.7 mmol), 50% aqueous acetic acid (160 ml), 35% aqueous HCl solution (7 ml) and 6 g Rh/C (5%). The reaction mixture was hydrogenated at 60 bar H2 at 120° C. for 24 hours. After cooling and filtration through Celite, the filtrate was evaporated to dryness and the residue further dried under reduced pressure. The residue was mixed with methanol (200 ml) and (9 ml, 0.123 mol) thionyl chloride and heated at 80° C. for 2 hours. After cooling, the reaction mixture was evaporated to dryness and the white solid further dried under reduced pressure to yield 13.6 g (92%) of 4,5,6,7-tetrahydro-1H-benzimidazole-5-carboxylic acid methyl ester hydrochloride. The hydrochloride was treated with saturated sodium hydrogen carbonate solution (300 ml) and extracted with DCM (3×300 ml) to obtain 10.8 g (81%) of 4,5,6,7-tetrahydro-1H-benzimidazole-5-carboxylic acid methyl ester as a white solid.

1. temperatureAfter cooling
2. filtrationfiltration through Celite
3. customthe filtrate was evaporated to dryness
4. customthe residue further dried under reduced pressure
5. temperatureAfter cooling
6. customthe reaction mixture was evaporated to dryness
7. customthe white solid further dried under reduced pressure

ORD record

ord-191ec7b555164004a370db6a618e4fe5

Source dataset

uspto-grants-2002_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06437147B1