Hydrochloric Acid → HCID 18459292, compound

HRID 2305017Notes

Reaction equation

HRID 2305017 reaction equation
[OH:1][C:2]([CH2:18][S:19]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)(=[O:21])=[O:20])([CH2:8][NH:9][C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11])[C:3]([O:5]CC)=[O:4].[OH-].[Na+].Cl>CO>[OH:1][C:2]([CH2:18][S:19]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=1)(=[O:20])=[O:21])([CH2:8][NH:9][C:10]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11])[C:3]([OH:5])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86589163HCID 86589163, compound

Product 1

HCID 18459292HCID 18459292, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-hydroxy-2-[(4-methoxybenzenesulfonyl)methyl]-3-(N-benzenecarbonylamino)-propionic acid, ethyl ester (0.27 g) in 4 mL of methanol is stirred with 1 mL of 1N sodium hydroxide for 3 hours. The reaction mixture is acidified with 1N HCl and the solvent is removed under reduced pressure. The residue is triturated twice with warm ethyl acetate. The ethyl acetate is removed, affording the title compound as a white solid.

Workup

  1. customthe solvent is removed under reduced pressure
  2. customThe residue is triturated twice with warm ethyl acetate
  3. customThe ethyl acetate is removed

Sources & evidence

ORD record
ord-d7174ce884a84f94b473502cd4d24a53
Source dataset
uspto-grants-2002_08
Patent number
US06437177B1

Reaction notes

Loading…