Water → HCID 9863961, compound

HRID 2305399Notes

Reaction equation

HRID 2305399 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1.[OH:18][C:19]1[CH:24]=[C:23]([OH:25])[N:22]=[C:21]([SH:26])[N:20]=1.N1CCCCC1.O>C(O)C>[F:17][C:2]([F:1])([F:16])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[O:15][C:12]([CH:13]=[C:24]2[C:23](=[O:25])[NH:22][C:21](=[S:26])[NH:20][C:19]2=[O:18])=[CH:11][CH:10]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8082PiperidineHCID 6882805-[2-(trifluoromethyl)phenyl]furan-2-carbaldehydeHCID 178516656HCID 178516656, compound

Product 1

HCID 9863961HCID 9863961, compoundYield 55.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A suspension of 0.242 g (1 mmol) of 5-(2-trifluoromethylphenyl)furfural, 0.144 g (1 mmol) of 4,6-dihydroxy-2-mercaptopyrimidine, and a drop of piperidine in 6 ml of ethanol was stirred with heating at 80° C. for 4 hours. Upon cooling, the orange suspension was poured into 50 ml of water and sonicated for 10 minutes. Filtration of the orange solvent and drying provided 0.204 g of the product as an orange powder.

Workup

  1. temperatureUpon cooling
  2. customsonicated for 10 minutes
  3. filtrationFiltration of the orange solvent
  4. customdrying

Sources & evidence

ORD record
ord-5f156160d9b741af8bc023ca346c1a87
Source dataset
uspto-grants-2002_08
Patent number
US06440985B1

Reaction notes

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