Methane → HCID 178454477, compound

HRID 2305474Notes

Reaction equation

HRID 2305474 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[OH:12])=[N:9][CH:8]=[CH:7][CH:6]=2.[C:13](Cl)(=[O:17])[CH2:14][CH2:15][CH3:16].C>>[OH:12][C:11]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][N:9]=2)[N:4]=[CH:3][C:2]=1[NH:1][C:13](=[O:17])[CH2:14][CH2:15][CH3:16]

Participants

4

Reactant 3

HCID 297MethaneHCID 8855Butyryl chlorideHCID 178508000HCID 178508000, compound

Product 1

HCID 178454477HCID 178454477, compoundYield 46.3%

Procedure

Using the general method of Example 57 Part B, 3-amino[1,5]naphthyridin-4-ol (1.8 g, 11.2 mmol) was reacted with butyryl chloride (1.3 g, 12.3 mmol) to provide 1.2 g of N-(4-hydroxy[1,5]naphthyridin-3-yl)butanamide as a charcoal gray solid, m.p.>360° C.

Sources & evidence

ORD record
ord-011a127d60ac49a8b1eefd93dcf24684
Source dataset
uspto-grants-2002_08
Patent number
US06440992B1

Reaction notes

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