Hydrochloric Acid → HCID 49801998, compound

HRID 2306004Notes

Reaction equation

HRID 2306004 reaction equation
C[O:2][C:3]([C@@H:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C@@H:6]1[NH:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:4].[ClH:18]>O>[CH2:8]1[CH2:7][C@@H:6]([C@@H:5]([C:3]([OH:4])=[O:2])[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:11][CH2:10][CH2:9]1.[ClH:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 6101852methyl (S)-phenyl((R)-piperidin-2-yl)acetate

Product 1

HCID 49801998HCID 49801998, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of dl-threo-methylphenidate (1 g) in water (25 ml) and conc. HCl (5 ml) was heated under reflux for 3 h. The clear solution was evaporated to dryness, to give a dl-threo-ritalinic acid hydrochloride as a white solid.

Workup

  1. temperatureunder reflux for 3 h
  2. customThe clear solution was evaporated to dryness

Sources & evidence

ORD record
ord-5b6f91eaed9743fca4c2f329b3aea8d3
Source dataset
uspto-grants-2002_08
Patent number
US06441178B2

Reaction notes

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