Hydrochloric Acid → HCID 9927981, compound

HRID 2306157Notes

Reaction equation

HRID 2306157 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][CH:11]([C:23]1[C:28]([CH3:29])=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:30])[CH2:12][O:13][CH2:14][C:15]1[C:20]([F:21])=[CH:19][CH:18]=[CH:17][C:16]=1[F:22])=O)(C)(C)C>C(OCC)(=O)C.C1(C)C=CC=CC=1>[ClH:1].[F:21][C:20]1[CH:19]=[CH:18][CH:17]=[C:16]([F:22])[C:15]=1[CH2:14][O:13][CH2:12][CH:11]([C:23]1[C:28]([CH3:29])=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:30])[CH2:10][NH2:9]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11188926HCID 11188926, compound

Product 1

HCID 9927981HCID 9927981, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8857Ethyl AcetateSolvent

Procedure

A strong current of HCl gas is piped into a solution of 23 g (57 mmol) of N-tert.-butoxycarbonyl-3-(2,6-difluorophenyl)methoxy-2-(2,6-dimethylphenyl)-propylamine in 23 ml of ethyl acetate for 3 min. The mixture is left to react for 30 min, the solvent is eliminated in vacuo and the residue taken up in 30 ml of toluene. The solvent is again eliminated in vacuo and the residue crystallised from ether. Yield: 18.5 g (95%), melting point: 123° C.

Workup

  1. waitThe mixture is left
  2. customto react for 30 min
  3. customthe residue crystallised from ether

Sources & evidence

ORD record
ord-4092c482dd764758b4a9d5865ccd9395
Source dataset
uspto-grants-2002_08
Patent number
US06441237B1

Reaction notes

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