反应详情

A solution of 4-bromobenzylisocyanate (408 mg, 1.92 mmol) in acetonitrile (15 ml) was treated with triethylamine (390 mg, 3.86 mmol) followed by pyrrolidine (137 mg, 1.93 mmol) at room temperature with stirring under argon. The reaction was stirred at 20° C. for 30 minutes and then partitioned between ethyl acetate (10 ml) and water (20 ml). The organic layer was dried over sodium sulphate and evaporated under reduced pressure to give the title compound as a colourless solid (542 mg, 99%).

1. stirringThe reaction was stirred at 20° C. for 30 minutes
2. custompartitioned between ethyl acetate (10 ml) and water (20 ml)
3. dry with materialThe organic layer was dried over sodium sulphate
4. customevaporated under reduced pressure