Hydrogen Bromide → HCID 18434234, compound

HRID 2306477Notes

Reaction equation

HRID 2306477 reaction equation
F[C:2]1[CH:10]=[C:9](F)[CH:8]=[CH:7]C=1C([Cl:6])=O.FC1C=CC(F)=CC=1OC.[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[C:30]([C:32]1[CH:37]=[C:36]([F:38])[C:35]([O:39][CH3:40])=[CH:34][C:33]=1[F:41])=[O:31].Br.BrCCCCCCBr.[CH2:51]([NH:54][CH3:55])[CH:52]=[CH2:53]>>[CH2:51]([N:54]([CH3:55])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:2][CH2:40][O:39][C:35]1[C:36]([F:38])=[CH:37][C:32]([C:30]([C:24]2[CH:25]=[CH:26][C:27]([F:29])=[CH:28][C:23]=2[F:22])=[O:31])=[C:33]([F:41])[CH:34]=1)[CH:52]=[CH2:53].[ClH:6]

Participants

7

Reactant 6

HCID 260Hydrogen BromideHCID 123681,6-DibromohexaneHCID 69391N-MethylallylamineHCID 5880812,4-Difluorobenzoyl chlorideHCID 27249892,5-DifluoroanisoleHCID 18434165HCID 18434165, compound

Product 1

HCID 18434234HCID 18434234, compound

Procedure

from 2,4-difluorobenzoyl chloride and 2,5-difluoroanisole via (2,4-difluoro-phenyl)-(2,5-difluoro-4-methoxy-phenyl)-methanone, which is deprotected with hydrogen bromide and reacted with 1,6-dibromohexane and N-allyl-methyl-amine, there is obtained [4-[6-(allyl-methyl-amino)-hexyloxy]-2,5-difluoro-phenyl]-(2,4-difluoro-phenyl)-methanone•hydrochloride (1:1), MS: m/e 423 (M),

Sources & evidence

ORD record
ord-f0c687e2b6c34d9987f87c884a52694d
Source dataset
uspto-grants-2002_08
Patent number
US06441177B1

Reaction notes

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