Hydrogen Bromide → HCID 10925342, compound

HRID 2306478Notes

Reaction equation

HRID 2306478 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[O:10])=[C:5]([S:11][CH3:12])[CH:4]=1.[BrH:13].C([O-])(O)=O.[Na+]>C(O)(=O)C>[Br:13][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][C:5]=2[S:11][CH3:12])=[O:10])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 516892Sodium BicarbonateHCID 14361744HCID 14361744, compound

Product 1

HCID 10925342HCID 10925342, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.0 g of 4-bromo-phenyl)-(4-methoxy-2-methylsulphanyl-phenyl)-methanone (Ex. C) are suspended in 6 ml of acetic acid and 3.5 ml of 62% HBr and stirred at 125° C. overnight. The suspension is added to sat. NaHCO3 solution, the phases are separated and the inorganic phase is extracted with ethyl acetate. The organic phases are washed with sat. NaHCO3 solution and with saturated sodium chloride solution and dried. 920 mg of (4-bromo-phenyl)-(4-hydroxy-2-methylsulphanyl-phenyl)-methanone are obtained as brown crystals.

Workup

  1. customthe phases are separated
  2. extractionthe inorganic phase is extracted with ethyl acetate
  3. washThe organic phases are washed with sat. NaHCO3 solution and with saturated sodium chloride solution
  4. customdried

Sources & evidence

ORD record
ord-19d56dc7416d46a78b77049f247b6f10
Source dataset
uspto-grants-2002_08
Patent number
US06441177B1

Reaction notes

Loading…