Pyridine → HCID 73985894, compound

HRID 2306623Notes

Reaction equation

HRID 2306623 reaction equation
Cl.[O:2]([NH2:4])[CH3:3].C([C:7](=[CH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:8]([OH:10])=[O:9])=O.N1C=CC=C[CH:19]=1>>[CH3:3][O:2][N:4]=[CH:19][C:15]1[CH:14]=[CH:13][C:12]([CH:11]=[CH:7][C:8]([OH:10])=[O:9])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 54183450HCID 54183450, compound

Product 1

HCID 73985894HCID 73985894, compound

Procedure

Methoxylamine hydrochloride (0.996 g, 0.0119 mol) is added to a solution of formylcinnamic acid (2 g, 0.0114 mol) in pyridine (20 ml) and is stirred for 2 hours. The reaction mixture is evaporated under vacuum and the residue is diluted with 2N aqueous HCl. The resulting precipitate is filtered and dried under vacuum (2.00 g, 85%).

Workup

  1. customThe reaction mixture is evaporated under vacuum
  2. additionthe residue is diluted with 2N aqueous HCl
  3. filtrationThe resulting precipitate is filtered
  4. customdried under vacuum (2.00 g, 85%)

Sources & evidence

ORD record
ord-90bfc2b87ca44e94b3720a8f4a4f0c65
Source dataset
uspto-grants-2004_12
Patent number
US06828317B2

Reaction notes

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