Triethylamine → HCID 22629929, compound

HRID 2306857Notes

Reaction equation

HRID 2306857 reaction equation
C(N(CC)CC)C.[Cl:8][C:9]1[C:10]([CH:19]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[NH2:20])=[N:11][CH:12]=[C:13]([C:15]([F:18])(F)F)[CH:14]=1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[C:31](Cl)=[O:32]>CN(C)C=O>[Cl:8][C:9]1[C:10]([CH:19]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[NH:20][C:31](=[O:32])[C:30]2[CH:34]=[CH:35][C:36]([O:37][CH3:38])=[C:28]([O:27][CH3:26])[CH:29]=2)=[N:11][CH:12]=[C:13]([CH2:15][F:18])[CH:14]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 77070Veratroyl chlorideHCID 12993938HCID 12993938, compound

Product 1

HCID 22629929HCID 22629929, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Triethylamine (0.28 ml) was added to a solution of ethyl 2-(3-chloro-5trifluoromethyl-2-pyridyl)glycinate (1 g; prepared in a similar manner to the starting material for Example 3) in dimethylformamide (10 ml) with stirring followed by 3,4-dimethoxybenzoyl chloride (0.70 g), the mixture was stirred for 45 minutes and evaporated. The residue was extracted with ethyl acetate and the extracts worked up to give the title product, m.p. 40-3° C. (Compound 601)

Workup

  1. stirringthe mixture was stirred for 45 minutes
  2. customevaporated
  3. extractionThe residue was extracted with ethyl acetate

Sources & evidence

ORD record
ord-ed9ab786875848398dbcffa6932c73c5
Source dataset
uspto-grants-2004_12
Patent number
US06828441B2

Reaction notes

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