Hydrochloric Acid → (3Z)-2-amino-5-cyano-2-methylpent-3-enoic Acid Hydrochloride

HRID 2306883Notes

Reaction equation

[K+].C(OC([NH:9][C:10]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:11]([O-:13])=[O:12])=O)(C)(C)C.[ClH:20]>O>[ClH:20].[NH2:9][C:10]([CH3:19])(/[CH:14]=[CH:15]\[CH2:16][C:17]#[N:18])[C:11]([OH:13])=[O:12]

Participants

Conditions

Temperature: 50 °C

Procedure

The (3Z)-2-[(tert-butoxycarbonyl)amino]-5-cyano-2-methylpent-3-enoic acid potassium salt product of Example 1j is taken up in DI water (80 mL) containing HCl. The reaction mixture is stirred at 50° C. for 2 h. and concentrated on a rotary evaporator to give the crude product. It is purified using a Gilson chromatographic system to provide the desired title product.

Workup

concentrationconcentrated on a rotary evaporator
customto give the crude product
customIt is purified

Sources & evidence

ORD record: ord-38dbc211c68f4fb4b56bb943aef3e8e3
Source dataset: uspto-grants-2004_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06828456B2

Reaction notes

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