1-Bromo-3-chlorobenzene → 3-Bromo-5-chlorophenol

Temperature

150 °C

To an airfree flask equipped with a stir bar, in a glove box, was added m-bromochlorobenzene (192 mg, 1.00 mmol), HBPin (200 mg, 1.56 mmol), (Ind)Ir(COD) (8.3 mg, 0.02 mmol), and dmpe (3.0 mg, 0.02 mmol). The flask was sealed, removed for the glove box, and stirred at 150° C. for 3 h. This material was used in next step without purification. To the crude material was added NaOH (1.5 mL of a 1.5M aqueous solution) and the resulting mixture was stirred for 5 minutes. To this was added NaHCO3 (0.73 g, 8.7 mmol) and acetone (3 mL). The mixture was cooled to 0° C. and OXONE (3.2 mL of a 0.33M aqueous solution) was added dropwise. The reaction mixture was stirred at 0° C. for 10 minutes and quenched with sodium bisulfite (2.0 g in 3 ml H2O). The grayish solution was diluted with ether (20 ml), and extracted with aq. 2 M HCl (1×25 ml). The aqueous layer was separated from the organic layer and extracted with ether (2×25 ml). Combined organic layers were washed with water (2×25 ml), dried with MgSO4, and solvents removed under reduced pressure. Crude material was passed through silica plug eluting with CH2Cl2 to give 163.4 mg (78.8%) of 3-bromo-5-chlorophenol as a white solid. In a separate run under the same conditions with twice the scale, 301.2 mg (72.4%) of desired phenol was obtained. mp=68-69° C. 1H NMR (CDCl3, 300 MHz) δ 7.08 (t, J=1.65 Hz, 1H), 6.89 (dd, J=2.2, 1.65 Hz, 1H), 6.78 (dd, J=2.2, 1.65 Hz, 1H), 4.83 (s, 1H). 13C NMR (CDCl3, 125 MHz) δ 156.6, 135.7, 124.1, 122.9, 117.4, 115.0. FT-IR (KBr) 3221, 3159, 3090, 3046, 2927, 2856, 2793, 2659, 2492, 1577, 1486, 1458, 1426, 1376, 1359, 1286, 1239, 1214, 1088, 913, 859, 840, 778, 666 cm−1. MS (rel. int.) m/z 208 (100), 206 (82), 127 (26), 99 (37), 63 (22). Anal. Calcd for C6H4BrClO: C, 34.74; H, 1.94; N, 0.00. Found: C, 35.08; H, 2.03; N, 0.07.

1. customTo an airfree flask equipped with a stir bar, in a glove box
2. customThe flask was sealed
3. customremoved for the glove box
4. customThis material was used in next step without purification
5. additionTo the crude material was added NaOH (1.5 mL of a 1.5M aqueous solution) and the resulting mixture
6. stirringwas stirred for 5 minutes
7. temperatureThe mixture was cooled to 0° C.
8. stirringThe reaction mixture was stirred at 0° C. for 10 minutes
9. customquenched with sodium bisulfite (2.0 g in 3 ml H2O)
10. additionThe grayish solution was diluted with ether (20 ml)
11. extractionextracted with aq. 2 M HCl (1×25 ml)
12. customThe aqueous layer was separated from the organic layer
13. extractionextracted with ether (2×25 ml)
14. washCombined organic layers were washed with water (2×25 ml)
15. dry with materialdried with MgSO4, and solvents
16. customremoved under reduced pressure
17. washeluting with CH2Cl2

ORD record

ord-5132822fc4bf46b38d4e6f150bb01ba2

Source dataset

uspto-grants-2004_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06828466B2