反应详情

Triethylamine (15 μl) and acetic anhydride (10 ml) were added to a stirred solution of (±)-3-[2,4-bis(methoxymethoxy)phenyl]cyclohexylamine (29 mg) in anhydrous 1,2-dichloroethane (2 ml) at room temperature. After 0.5 hr, the reaction mixture was partitioned between water (20 ml) and ethyl acetate (50 ml) and the aqueous layer was extracted with ethyl acetate (3×20 ml). The combined organic extracts were dried over magnesium sulfate and evaporated in vacuo to give the title compound as a solid (22 mg, 66%) and a mixture of diastereoisomers; m/z (ES+) 338 (M+H)+.

1. customthe reaction mixture was partitioned between water (20 ml) and ethyl acetate (50 ml)
2. extractionthe aqueous layer was extracted with ethyl acetate (3×20 ml)
3. dry with materialThe combined organic extracts were dried over magnesium sulfate
4. customevaporated in vacuo