Hydrochloric Acid → HCID 22605938, compound

HRID 2307274Notes

Reaction equation

HRID 2307274 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[CH:16]=[C:15]([NH:17][C:18](=O)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:14]=[CH:13][N:12]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].Cl>>[CH2:18]([NH:17][C:15]1[CH:14]=[CH:13][N:12]=[C:11]([N:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:1]2)[CH:16]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 21226445Aluminium lithium hydrideHCID 22605916HCID 22605916, compound

Product 1

HCID 22605938HCID 22605938, compound

Procedure

Following the general method described in example 9, N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-pyridin-4-yl]-benzamide (example 17a) was reacted with lithium aluminum hydride. After workup and chromatography the free base of the title compound was treated with hydrogen chloride and triturated with Et2O/pentane. The title compound was obtained as white amorphous material. MS: m/e=315 (M+).

Sources & evidence

ORD record
ord-66bf7990d62b40dba2c74f5ada7326b1
Source dataset
uspto-grants-2004_12
Patent number
US06831087B2

Reaction notes

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