Hydrochloric Acid → HCID 22605931, compound

HRID 2307276Notes

Reaction equation

HRID 2307276 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[N:16]=[C:15]([C:17]([NH2:19])=O)[CH:14]=[CH:13][CH:12]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[ClH:26]>>[ClH:26].[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[N:16]=[C:15]([CH2:17][NH2:19])[CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 21226445Aluminium lithium hydrideHCID 69896191HCID 69896191, compound

Product 1

HCID 22605931HCID 22605931, compound

Procedure

Following the general method described in example 9, 6-(3,4-dihydro-1H-isoquinolin-2-yl)-pyridine-2-carboxylic acid amide (example 22a) was reacted with lithium aluminum hydride. After workup and chromatography the free base of the title compound was treated with hydrogen chloride and crystallized as the off white salt. Mp. 192-195° C. (iPr2O), MS: m/e=239 (M+).

Sources & evidence

ORD record
ord-ea826b4102004fc681a213fbab23ad78
Source dataset
uspto-grants-2004_12
Patent number
US06831087B2

Reaction notes

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