Hydrochloric Acid → HCID 69863681, compound

HRID 2307444Notes

Reaction equation

HRID 2307444 reaction equation
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N:16]2[CH2:21][C@H:20]([CH3:22])[O:19][C@H:18]([CH3:23])[CH2:17]2)[CH:11]=1)[CH3:9])(C)(C)C.[ClH:25]>CO>[ClH:25].[CH3:22][C@H:20]1[O:19][C@@H:18]([CH3:23])[CH2:17][N:16]([C:12]2[CH:11]=[C:10]([C@@H:8]([NH2:7])[CH3:9])[CH:15]=[CH:14][CH:13]=2)[CH2:21]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69850021HCID 69850021, compound

Product 1

HCID 69863681HCID 69863681, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of {1-[3-(cis-2,6-dimethylmorpholin-4-yl)phenyl]-ethyl}carbamic acid tert-butyl ester (2.12 g, 6.35 mmol), and hydrochloric acid (1.0M solution in diethyl ether) (15.9 mmol, 2.5eq) in methanol (5 ml) was stirred at room temperature overnight. Concentrated under vacuum and 2 g of hydrochloric acid salt of (S)-1-[3-(cis-2,6-dimethylmorpholin-4-yl)phenyl]-ethylamine was obtained as yellow solid (quantitative yield).

Workup

  1. concentrationConcentrated under vacuum and 2 g of hydrochloric acid salt of (S)-1-[3-(cis-2,6-dimethylmorpholin-4-yl)phenyl]-ethylamine

Sources & evidence

ORD record
ord-7f169a15cf6646bb884e31d1697457eb
Source dataset
uspto-grants-2004_12
Patent number
US06831080B2

Reaction notes

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