Acetyl chloride → HCID 69919591, compound

HRID 2307470Notes

Reaction equation

HRID 2307470 reaction equation
[C:1]1([CH:7]=[CH:8][C:9]([NH:11][CH:12]([C:14]2[CH:23]=[C:22]3[C:17]([CH2:18][CH2:19][CH2:20][NH:21]3)=[CH:16][CH:15]=2)[CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:31](Cl)(=[O:33])[CH3:32]>C(Cl)Cl>[C:31]([N:21]1[C:22]2[C:17](=[CH:16][CH:15]=[C:14]([CH:12]([NH:11][C:9](=[O:10])[CH:8]=[CH:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH3:13])[CH:23]=2)[CH2:18][CH2:19][CH2:20]1)(=[O:33])[CH3:32]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 69850326HCID 69850326, compound

Product 1

HCID 69919591HCID 69919591, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-phenyl-N-[1-(1,2,3,4-tetrahydro-quinolin-7-yl)-ethyl]-acrylamide (Example 233) in CH2Cl2 at 0° C. was added triethylamine followed by acetyl chloride. Work up and flash chromatography provided the title compound.

Sources & evidence

ORD record
ord-2aa046afc70d4dd88d46cbf5181f84d0
Source dataset
uspto-grants-2004_12
Patent number
US06831080B2

Reaction notes

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