反应详情

温度

25 °C

A mixture of 9.2 g (83.4 mmol) of 2-acetylfuran, 20 ml (2.0 eq) of 4-fluorobenzylchloride and 22.8 g (2.0 eq) of zinc chloride were stirred at 25° C. for 20 hours. The stirring gradually became difficult due to the precipitate. The mixture was dissolved in water and extracted with ethylacetate. The organic layer was washed with water and a diluted sodium hydrogencarbonate aqueous solution and dried over sodium sulfate. The solvent was removed under deduced pressure. A fractional distillation under reduced pressure of the residue gave 9.6 g of 2-acetyl-5-(4-fluorobenzyl)furan. Yield: 53%. 2 mmHg/120-125° C.

1. extractionextracted with ethylacetate
2. washThe organic layer was washed with water
3. dry with materiala diluted sodium hydrogencarbonate aqueous solution and dried over sodium sulfate
4. customThe solvent was removed under deduced pressure
5. distillationA fractional distillation under reduced pressure of the residue