Potassium Carbonate → Methyl 3'-[3,4-bis(1-phenylmethanoyloxymethyl)benzyloxy]-2'-methylbiphenyl-4-carboxylate

HRID 2307558Notes

Reaction equation

HRID 2307558 reaction equation
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:19]([O:27][CH2:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[CH2:37][O:38][C:39](=[O:46])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH2:32]Br)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>>[C:20]1([C:19]([O:27][CH2:28][C:29]2[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=2[CH2:37][O:38][C:39]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:46])[CH2:32][O:1][C:2]2[C:3]([CH3:18])=[C:4]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:10][CH:9]=3)[CH:5]=[CH:6][CH:7]=2)=[O:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 223456183,4-Bis(benzoyloxymethyl)benzyl bromideHCID 22606879Methyl 3'-hydroxy-2'-methylbiphenyl-4-carboxylate

Product 1

HCID 22606934Methyl 3'-[3,4-bis(1-phenylmethanoyloxymethyl)benzyloxy]-2'-methylbiphenyl-4-carboxylate

Procedure

In a manner similar to that of Example 1(i), by reaction of 1 g (4.1 mmol) of methyl 3′-hydroxy-2′-methylbiphenyl-4-carboxylate with 2 g (4.5 mmol) of 3,4-bis(benzoyloxymethyl)benzyl bromide and 650 mg (4.7 mmol) of potassium carbonate, the desired product is obtained in the form of a colourless oil (m=2.4 9; Y=97%).

Sources & evidence

ORD record
ord-a9b9a78a925c4cc8a95341a865cd05f0
Source dataset
uspto-grants-2004_12
Patent number
US06831106B1

Reaction notes

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