Potassium Carbonate → Methyl 3'-[3,4-bis-(1-phenylmethanoyloxymethyl)benzyloxy]-3-methylbiphenyl-4-carboxylate

HRID 2307582Notes

Reaction equation

HRID 2307582 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[C:10]([CH3:18])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:19]([O:27][CH2:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[CH2:37][O:38][C:39](=[O:46])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH2:32]Br)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>>[C:20]1([C:19]([O:27][CH2:28][C:29]2[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=2[CH2:37][O:38][C:39]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:46])[CH2:32][O:1][C:2]2[CH:3]=[C:4]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[C:10]([CH3:18])[CH:9]=3)[CH:5]=[CH:6][CH:7]=2)=[O:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 223456183,4-Bis(benzoyloxymethyl)benzyl bromideHCID 22606892Methyl 3'-hydroxy-3-methylbiphenyl-4-carboxylate

Product 1

HCID 22606954Methyl 3'-[3,4-bis-(1-phenylmethanoyloxymethyl)benzyloxy]-3-methylbiphenyl-4-carboxylate

Procedure

In a manner similar to that of Example 1(i), by reaction of 1.5 g (6.2 mmol) of methyl 3′-hydroxy-3-methylbiphenyl-4-carboxylate with 3 g (6.88 mmol) of 3,4-bis(benzoyloxymethyl)benzyl bromide and 900 mg (6.4 mmol) of potassium carbonate, the desired product is obtained in the form of a yellow oil (m=3.69 g; Y=99%).

Sources & evidence

ORD record
ord-5cd81acb0b4442bda9a5afd6201d22b2
Source dataset
uspto-grants-2004_12
Patent number
US06831106B1

Reaction notes

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