Potassium Carbonate → Methyl 4'-[3,4-bis-(1-phenylmethanoyloxymethyl)-benzyloxy]-2-methylbiphenyl-4-carboxylate

HRID 2307585Notes

Reaction equation

HRID 2307585 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:10][C:9]=2[CH3:18])=[CH:4][CH:3]=1.[C:19]([O:27][CH2:28][C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=1[CH2:37][O:38][C:39](=[O:46])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH2:32]Br)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>>[C:20]1([C:19]([O:27][CH2:28][C:29]2[CH:30]=[C:31]([CH:34]=[CH:35][C:36]=2[CH2:37][O:38][C:39]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:46])[CH2:32][O:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:10][C:9]=3[CH3:18])=[CH:6][CH:7]=2)=[O:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 223456183,4-Bis(benzoyloxymethyl)benzyl bromideHCID 22606882Methyl 4'-hydroxy-2-methylbiphenyl-4-carboxylate

Product 1

HCID 22606924Methyl 4'-[3,4-bis-(1-phenylmethanoyloxymethyl)-benzyloxy]-2-methylbiphenyl-4-carboxylate

Procedure

In a manner similar to that of Example 1(i), by reaction of 2.0 g (8.7 mmol) of methyl 4′-hydroxy-2-methylbiphenyl-4-carboxylate with 4.3 g (9.8 mmol) of 3,4-bis(benzoyloxymethyl)benzyl bromide and 1.29 g (9.3 mmol) of potassium carbonate, the desired product is obtained in the form of a yellow oil (m=4.88 g; Y=91%).

Sources & evidence

ORD record
ord-ab2ac7296859449eaeee6a9b07d72f83
Source dataset
uspto-grants-2004_12
Patent number
US06831106B1

Reaction notes

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