反应详情

Palladium acetate (117 mg), 1,1′-bis(diphenylphosphino)ferrocene (577 mg) and triethylamine (1.4 mL) were added to an ethanol-DMF mixed solvent (1/1, 30 mL) of 2-bromo-5-chloropyridine (1.0 g), and stirred overnight in a carbon monoxide atmosphere (1 atmospheric pressure) at 50° C. Ethanol was evaporated off under reduced pressure from the reaction solution, water was added to the resulting residue, and extracted with hexane/ethyl acetate (2/3). The organic layer was dried with anhydrous magnesium sulfate, and the solvent was evaporated off under reduced pressure. The resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=9/1 to 4/1) to obtain the entitled compound (1.4 g).

1. customEthanol was evaporated off under reduced pressure from the reaction solution, water
2. additionwas added to the resulting residue
3. extractionextracted with hexane/ethyl acetate (2/3)
4. dry with materialThe organic layer was dried with anhydrous magnesium sulfate
5. customthe solvent was evaporated off under reduced pressure
6. customThe resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=9/1 to 4/1)