Methanol → Methyl 4-bromo-2-methylbenzoate

HRID 2307773Notes

Reaction equation

HRID 2307773 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:11])[CH:3]=1.[CH3:12]O>Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:12])=[O:7])=[C:4]([CH3:11])[CH:3]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 995704-Bromo-2-methylbenzoic acid

Product 1

HCID 22031226Methyl 4-bromo-2-methylbenzoateYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

A solution of 4-bromo-2-methyl benzoic acid (1.0 g, 4.7 mmol) in methanol (24 mL) was treated with 20 drops of HCl, heated at reflux for 6 hours, and concentrated to provide the desired product (1.07 g, 100%).

Workup

  1. temperatureheated
  2. temperatureat reflux for 6 hours
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-98d9bf2f222f4895a899c773c23506c4
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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