Ethanol → HCID 85843425, compound

HRID 2307786Notes

Reaction equation

HRID 2307786 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=O)[CH2:6][CH2:5]2.C([O:16][N:17]=O)(C)(C)C.C([OH:21])C>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8]([CH2:7][C:6](=[O:21])[C:5]2=[N:17][OH:16])=[CH:9][CH:10]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 10906Tert-Butyl nitriteHCID 5206955-Bromo-1-indanone

Product 1

HCID 85843425HCID 85843425, compoundYield 76%

Procedure

A solution of 5-bromo-1-indanone (1.8 g, 8.5 mmol) in ethanol (150 ml) was cooled to 0° C., treated with t-butylnitrite (2.1 ml), stirred at room temperature for 2 hours, filtrated and washed the desired product with ether. The yield is 76%. MS (DCI/NH3) m/e 242 (M+1)+.

Workup

  1. filtrationfiltrated
  2. washwashed the desired product with ether

Sources & evidence

ORD record
ord-b1c7980cd0bd486aabc9167f6b438dbb
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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