Hydrochloric Acid → 5-Bromo-2-fluorobenzoic acid

HRID 2307790Notes

Reaction equation

HRID 2307790 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[OH-:11].[Na+].OO.Cl>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:10])=[C:6]([CH:9]=1)[C:7]([OH:11])=[O:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 7363275-Bromo-2-fluorobenzaldehyde

Product 1

HCID 27363155-Bromo-2-fluorobenzoic acidYield 77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5-bromo-2-fluorobenzaldehyde (810 mg; 4.0 mmol), 15% NaOH (aq.) (3 mL), MeOH (5 mL), and 30% H2O2 (5 mL) was stirred at r.t. for 2 hrs., then acidified with 10% HCl (aq.). The resulting white solid was collected, rinsed with water, and dried to give the desired product (670 mg; 77%).

Workup

  1. customThe resulting white solid was collected
  2. washrinsed with water
  3. customdried

Sources & evidence

ORD record
ord-a440ca0bf6eb43d998431190a8ba0865
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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