Hydrochloric Acid → HCID 131724693, compound

HRID 2307853Notes

Reaction equation

HRID 2307853 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]2[CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[CH:17][CH:18]=3)[N:13]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[F:27])[N:12]=2)[N:3]=1.[ClH:28]>C(#N)C>[ClH:28].[NH2:1][C:2]1[C:7]([CH:8]2[CH2:9][CH2:10]2)=[CH:6][N:5]=[C:4]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[CH:17][CH:18]=3)[N:13]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[F:27])[N:12]=2)[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9798973BAY-41-2272

Product 1

HCID 131724693HCID 131724693, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.3 g (0.83 mmol) of 3-(4-amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine from Example 1 is dissolved in 50 ml of hot acetonitrile, and 0.9 ml of 1 N HCl (0.9 mmol) is added. The precipitated crystals are subsequently filtered off with suction.

Workup

  1. filtrationThe precipitated crystals are subsequently filtered off with suction

Sources & evidence

ORD record
ord-3f199e88a62147fe8d15c94d3329e5d5
Source dataset
uspto-grants-2004_12
Patent number
US06833364B1

Reaction notes

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