Methyl 4-Formylbenzoate → HCID 23290824, compound

HRID 230787Notes

Reaction equation

HRID 230787 reaction equation
[P:1]([O-:8])([O:5][CH2:6][CH3:7])[O:2][CH2:3][CH3:4].[CH:9]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([O:19][CH3:20])=[O:18])=[CH:13][CH:12]=1)=[O:10].[F-].[K+]>C(Cl)(Cl)Cl>[CH2:3]([O:2][P:1]([CH:9]([OH:10])[C:11]1[CH:12]=[CH:13][C:14]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:16]=1)([O:5][CH2:6][CH3:7])=[O:8])[CH3:4]

Participants

5

Reactant 3

HCID 15294Methyl 4-FormylbenzoateHCID 522689Potassium FluorideHCID 3780918Diethylphosphite

Product 1

HCID 23290824HCID 23290824, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Diethyl phosphite (16 mL) was added to methyl 4-formylbenzenecarboxylate (10.2 g) and potassium fluoride (18.0 g), and stirred at room temperature for 30 minutes. The reaction liquid was diluted with chloroform (200 mL) added thereto, and filtrated through Celite. The solvent was evaporated off under reduced pressure from the filtrate, and the resulting solid was washed with diethyl ether to obtain the entitled compound (14.1 g) as a colorless solid.

Workup

  1. customThe reaction liquid
  2. additionadded
  3. filtrationfiltrated through Celite
  4. customThe solvent was evaporated off under reduced pressure from the filtrate
  5. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-0bb8cd392bfd44cc93a580e9bad16847
Source dataset
uspto-grants-2009_07
Patent number
US07566781B2

Reaction notes

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