Methylamine → 2-(4-Chloro-2,6-dimethyl-phenoxy)-4-(S,S)-(1-ethyl-2-methylamino-propylamino)-6-methyl-nicotinic acid methyl ester

HRID 2308006Notes

Reaction equation

HRID 2308006 reaction equation
[CH3:1][O:2][C:3](=[O:28])[C:4]1[C:9]([NH:10][CH:11]([CH2:15][CH3:16])[C:12](=O)[CH3:13])=[CH:8][C:7]([CH3:17])=[N:6][C:5]=1[O:18][C:19]1[C:24]([CH3:25])=[CH:23][C:22]([Cl:26])=[CH:21][C:20]=1[CH3:27].[CH3:29][NH2:30]>>[CH3:1][O:2][C:3](=[O:28])[C:4]1[C:9]([NH:10][C@@H:11]([CH2:15][CH3:16])[C@@H:12]([NH:30][CH3:29])[CH3:13])=[CH:8][C:7]([CH3:17])=[N:6][C:5]=1[O:18][C:19]1[C:24]([CH3:25])=[CH:23][C:22]([Cl:26])=[CH:21][C:20]=1[CH3:27]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 695875392-(4-Chloro-2,6-dimethyl-phenoxy)-4-(1-ethyl-2-oxo-propylamino)-6-methyl-nicotinic acid methyl ester

Product 1

HCID 698995282-(4-Chloro-2,6-dimethyl-phenoxy)-4-(S,S)-(1-ethyl-2-methylamino-propylamino)-6-methyl-nicotinic acid methyl ester

Procedure

The title compound was prepared by a reductive amination as shown above starting with 2-(4-Chloro-2,6-dimethyl-phenoxy)-4-(1-ethyl-2-oxo-propylamino)-6-methyl-nicotinic acid methyl ester and methyl amine. APCl M+1 [420.2], 1H NMR(CDCl3)

Sources & evidence

ORD record
ord-465029b0f46c4d0a8767cf2773ca59b7
Source dataset
uspto-grants-2004_12
Patent number
US06833378B2

Reaction notes

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