p-Fluorotoluene-alpha-thiol → HCID 86593389, compound

HRID 2308050Notes

Reaction equation

HRID 2308050 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]#[CH:12].[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][SH:19])=[CH:16][CH:15]=1.[Na]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1/[CH:11]=[CH:12]\[CH:18]([S:19][CH:18](/[CH:12]=[CH:11]\[C:4]1[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[CH:8][C:3]=1[O:2][CH3:1])[C:17]1[CH:20]=[CH:21][C:14]([F:13])=[CH:15][CH:16]=1)[C:17]1[CH:20]=[CH:21][C:14]([F:13])=[CH:15][CH:16]=1

Participants

4

Reactant 3

HCID 85171p-Fluorotoluene-alpha-thiolHCID 5360545SodiumHCID 15184633Benzene, 1-ethynyl-2,4-diMethoxy-

Product 1

HCID 86593389HCID 86593389, compound

Procedure

A solution of 2,4-dimethoxyphenylacetylene (0.02 mol), 4-fluorobenzyl mercaptan (0.02 mol) and metallic sodium (0.02 g atom) is subjected to the General Procedure to form (Z)-2,4-dimethoxystyryl-4-fluorobenzylsulfide. The title compound is obtained following oxidation of the sulfide, according to the General Procedure.

Sources & evidence

ORD record
ord-c5e58107981f46df813c185c98c4ea99
Source dataset
uspto-grants-2004_12
Patent number
US06833480B2

Reaction notes

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