1-Ethynyl-2,4-difluorobenzene → HCID 86593402, compound

HRID 2308063Notes

Reaction equation

HRID 2308063 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]#[CH:10].[NH2:11][C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14][SH:15].[Na]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1/[CH:9]=[CH:10]\[CH:14]([S:15][CH:14](/[CH:10]=[CH:9]\[C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])[C:13]1[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=1[NH2:11])[C:13]1[CH:16]=[CH:17][CH:18]=[CH:19][C:12]=1[NH2:11]

Participants

4

Reactant 3

HCID 50638201-Ethynyl-2,4-difluorobenzeneHCID 5360545SodiumHCID 20488107HCID 20488107, compound

Product 1

HCID 86593402HCID 86593402, compound

Procedure

A solution of 2,4-difluorophenylacetylene (0.02 mol), 2-aminobenzyl mercaptan (0.02 mol) and metallic sodium (0.02 g atom) is subjected to the General Procedure to form (Z)-2,4-difluorostyryl-2-aminobenzylsulfide. The title compound is obtained following oxidation of the sulfide, according to the General Procedure.

Sources & evidence

ORD record
ord-7bf3e3b8055c4a728950f0be9fcbff75
Source dataset
uspto-grants-2004_12
Patent number
US06833480B2

Reaction notes

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