反应详情

温度

-78 °C

In a 2 liter three-neck flask equipped with a stirrer and a thermometer, 100 g (0.6 mol) of fluorene was dissolved in 1 l of tetrahydrofuran and the flask was cooled sufficiently to −78° C. With an injector, 264 ml (1.32 mol) of 2.5M n-butyl lithium which was diluted in hexane was slowly added dropwise into the flask. When the addition of the same was finished, the above cooled temperature was maintained for thirty minutes, and then the flask was stirred at room temperature for one hour. Then again the resultant material was cooled down to −78° C. 88.44 ml (1.26 mol) of hexyl bromide was added into the flask using an injector. When the above procedure was finished, after keeping the temperature for thirty minutes, the flask was stirred at room temperature for 24 hours. When the reaction was finished, a small amount of cooled distilled water was poured to the resultant solution and the resultant solution was stirred for 2 to 3 minutes. When layers were separated, the organic layer was extracted using ether three times and it was washed by water several times. Then the resultant materials were dried using anhydrous magnesium sulfate and after removing the solvent, the resultant materials were purified with column, to obtain 132 g (88% t yield) of the entitled product as a pale yellowish viscous oil. 1H-NMR (CDCl3) δ 0.6-1.41 (m, 8H, CH2, 3H, CH3), 2.08-2.12 (m, 4H, CCH2), 4.07-4.18 (t, 1H, CH), 7.39-7.92 (m, 8H, Aromatic).

1. customIn a 2 liter three-neck flask equipped with a stirrer
2. additionwas slowly added dropwise into the flask
3. additionWhen the addition of the
4. temperaturethe above cooled temperature was maintained for thirty minutes
5. customfor thirty minutes
6. stirringthe flask was stirred at room temperature for 24 hours
7. temperaturea small amount of cooled
8. distillationdistilled water
9. additionwas poured to the resultant solution
10. stirringthe resultant solution was stirred for 2 to 3 minutes
11. customWhen layers were separated
12. extractionthe organic layer was extracted
13. washwas washed by water several times
14. dry with materialThen the resultant materials were dried
15. customafter removing the solvent
16. customthe resultant materials were purified with column
17. customto obtain