反应详情

To ethyl acetate (20 ml) containing 1-benzyloxycarbonylmethyl-3-(tert-butoxycarbonylmethyl)-2,4-dioxopyrimidine (1.2 g) obtained in Example 2 is added a 20% palladium hydroxide (50 mg), and the mixture is stirred at room temperature under hydrogen atmosphere for one hour. The catalyst is removed by filtration, and the filtrate is concentrated under reduced pressure to give the desired 2-(3-tert-butoxycarbonylmethyl-2,4-dioxo-1-pyrimidinyl)acetic acid (0.7 g) as colorless powder.

1. customThe catalyst is removed by filtration
2. concentrationthe filtrate is concentrated under reduced pressure