Methanol → HCID 178493814, compound

HRID 2308192Notes

Reaction equation

HRID 2308192 reaction equation
[NH2:1][C:2]1[C:3]([C:15]([OH:17])=O)=[CH:4][C:5]2[O:10][CH:9](COC)[CH2:8][O:7][C:6]=2[CH:14]=1.[N:18]1[CH:23]=CC=NN=1.N1CCCCC1.[CH3:30][OH:31]>>[CH3:30][O:31][CH:9]1[O:10][C:5]2[CH:4]=[C:3]3[C:2](=[CH:14][C:6]=2[O:7][CH2:8]1)[N:1]=[CH:23][N:18]=[C:15]3[OH:17]

Participants

5

Reactant 4

HCID 887MethanolHCID 8082PiperidineHCID 1230471,2,3-TriazineHCID 12134602HCID 12134602, compound

Product 1

HCID 178493814HCID 178493814, compound

Procedure

The titled compound of Example 5 (0.367 g, 1.53 mmol), triazine (0.19 g, 2.3 mmol) and piperidine (0.015 ml, 0.153 mmol) was dissolved in 10 ml of methanol, followed by refluxing for 4 hours to obtain a white solid, which was then cooled down to a room temperature. The solid compound was filtered, washed with methanol and dried under vacuum to prepare the titled compound (0.240 g, 63%, m.p. 246-251° C.).

Workup

  1. temperatureby refluxing for 4 hours
  2. customto obtain a white solid, which
  3. filtrationThe solid compound was filtered
  4. washwashed with methanol
  5. customdried under vacuum
  6. customto prepare the titled compound (0.240 g, 63%, m.p. 246-251° C.)

Sources & evidence

ORD record
ord-ee1db21b02d64757861454f8b7c9a72a
Source dataset
uspto-grants-2004_12
Patent number
US06835735B2

Reaction notes

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