反应详情

To a stirred solution of Intermediate 24 (0.087 g) in 2:2:1 tetrahydrofuran:methanol:water (5 ml) was added lithium hyroxide (0.149 g) and the mixture stirred at room temperature for 47 h, then at 60° C. for 2.5 h. The solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The aqueous layer was re-extracted with dichloromethane and the combined organic layers dried over sodium sulphate and concentrated in vacuo to give the title compound as a colourless oil (0.049 g).

1. waitat 60° C. for 2.5 h
2. customThe solvent was removed in vacuo
3. customthe residue partitioned between ethyl acetate and water
4. extractionThe aqueous layer was re-extracted with dichloromethane
5. dry with materialthe combined organic layers dried over sodium sulphate
6. concentrationconcentrated in vacuo