反应详情

A mixture containing Intermediate 65 (0.15 g), 10% palladium on activated carbon (0.04 g) and triethylamine (5 ml) in ethanol (25 ml) and N,N-dimethylformamide (10 ml) was hydrogenated at room temperature for 4 h. The suspension was filtered through celite, the residue washed with ethanol/N,N-dimethylformamide (3:1, 50 ml), and the filtrate concentrated in vacuo. The residue was purified by mass directed preparative HPLC (Method A) to give the title compound as a yellow solid (0.035 g).

1. filtrationThe suspension was filtered through celite
2. washthe residue washed with ethanol/N,N-dimethylformamide (3:1, 50 ml)
3. concentrationthe filtrate concentrated in vacuo
4. customThe residue was purified by mass