Hydrochloric Acid → HCID 13958008, compound

HRID 2308714Notes

Reaction equation

HRID 2308714 reaction equation
[C:1]1([CH2:7][C:8]([CH:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12][C:11]2=[O:19])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21].Cl>O>[C:20]([N:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]([C:8](=[O:9])[CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:11]1=[O:19])(=[O:22])[CH3:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 3387567HCID 3387567, compound

Product 1

HCID 13958008HCID 13958008, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-(2-Phenylacetyl)-2-oxindole was acetylated with acetic anhydride using the procedure of Example 7. When the reaction mixture was poured into a mixture of 3N hydrochloric acid and water, a solid formed. The solid was recovered by filtration and recrystallized from isopropanol to give a 40% yield of the title compound, m.p. 149°-151° C.

Workup

  1. customa solid formed
  2. filtrationThe solid was recovered by filtration
  3. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-e708f0f40f55468099619cbc9aeb1c25
Source dataset
uspto-grants-1987_09
Patent number
US04690943

Reaction notes

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