Hydrochloric Acid → 2-chloro-N-phenylpropanamide

HRID 2308735Notes

Reaction equation

HRID 2308735 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:8][CH:9]([CH3:13])[C:10](Cl)=[O:11].Cl>>[Cl:8][CH:9]([CH3:13])[C:10]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 1110192-Chloropropionyl chloride

Product 1

HCID 2646462-chloro-N-phenylpropanamideYield 94.8%

Procedure

18 g of aniline are introduced dropwise into 22.6 g of 2-chloropropionyl chloride at a temperature of about 10° C., with stirring until the evolution of HCl has ended. After filtration, 31 g (yield: 84.5%) of α-chloro-α-methylacetanilide are obtained in the form of a pink powder. M.p. (inst.)=80° C.

Sources & evidence

ORD record
ord-6faf5a65b2ed4d0181fcc5ef07c89e82
Source dataset
uspto-grants-1987_09
Patent number
US04690950

Reaction notes

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