Sodium Carbonate → HCID 45258253, compound

HRID 2308750Notes

Reaction equation

HRID 2308750 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].Br[CH:21]([CH3:30])[C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:23]>C(O)C>[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH:21]([CH3:30])[C:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:23])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 164522-BromopropiophenoneHCID 317384-Benzylpiperidine

Product 1

HCID 45258253HCID 45258253, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

17.5 g (0.1 mol) of 4-benzylpiperidine and then 12 g of sodium carbonate are added to a solution of 21.3 g (0.1 mol) of 2-bromopropiophenone in 100 ml of ethanol, and the mixture is heated under reflux for 2 hours. It is then filtered and the solvent is driven off. An oil remains, which is used as such in the subsequent reduction.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 2 hours
  3. filtrationIt is then filtered

Sources & evidence

ORD record
ord-fba660146e1340f4aa25db3646c0bd2a
Source dataset
uspto-grants-1987_09
Patent number
US04690931

Reaction notes

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