Hydrochloric Acid → [1,3]Thiazolo[5,4-b]pyridin-2-amine

HRID 2308959Notes

Reaction equation

HRID 2308959 reaction equation
Cl[C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[S-:9][C:10]#[N:11].[K+].Cl>C(O)C>[NH2:11][C:10]1[S:9][C:2]2[C:7]([N:8]=1)=[CH:6][CH:5]=[CH:4][N:3]=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 805282-Chloro-3-pyridylamineHCID 516872Potassium thiocyanate

Product 1

HCID 592050[1,3]Thiazolo[5,4-b]pyridin-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The method described in J. Het. Chem., 14(1), 129(1977) was followed to react 2-chloro-3-aminopyridine with potassium thiocyanate and hydrochloric acid in ethanol to produce 45.3 g of 2-aminothiazolo[5,4-b]pyridine. M+Theory 151; Found 151.

Sources & evidence

ORD record
ord-e0cd48ffacc248d99dbf02c05a61ca68
Source dataset
uspto-grants-1987_09
Patent number
US04692443

Reaction notes

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