反应详情

A solution of 1.2 g of the compound from Example 2 and 1.3 g of methyl N-(4,6-dimethoxypyrimidin-2-yl)carbamate in 50 ml of methylene chloride was stirred under nitrogen and 3.4 ml of a 2N solution of trimethylaluminum in toluene was added. After heating at reflux for 4 days, the solution was cooled to 0°, 3 ml of 2N HCl (aq.) was added, the mixture was partitioned between methylene chloride and water. The organic layer was concentrated and the residue was chromatographed on silica gel to afford 0.9 g of the product, m.p. 175°-176°. NMR (DMSO-d6)δ: 3.8 (s, 6), 6.0 (s, 1), 7.2-8.3 (m). m/e (M+ +1) 416. IR 1700 cm-1.

1. temperatureAfter heating
2. temperatureat reflux for 4 days
3. temperaturethe solution was cooled to 0°
4. customthe mixture was partitioned between methylene chloride and water
5. concentrationThe organic layer was concentrated
6. customthe residue was chromatographed on silica gel