反应详情

A solution of 4-(phenoxycarbonylamino)pyridine (4.284 g), N-amino-1,2,3,6-tetrahydropyridine hydrochloride (4.038 g) and triethylamine (3.036 g) in chloroform (70 ml) was refluxed for 20 hours. After evaporation of chloroform, the residue was extracted with ethyl acetate (200 ml). The extract was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was chromatographed on silica gel (52 g) using chloroform to give N-[(4-pyridylcarbamoyl)amino]-1,2,3,6-tetrahydropyridine (2.005 g).

1. customAfter evaporation of chloroform
2. extractionthe residue was extracted with ethyl acetate (200 ml)
3. washThe extract was washed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo
6. customThe residue was chromatographed on silica gel (52 g)