Hydrochloric Acid → HCID 135838385, compound

HRID 2309268Notes

Reaction equation

HRID 2309268 reaction equation
C([O:4][C:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:16])(=[O:15])[N:7]([CH3:17])[C:6]=1[C:18]1[O:22][C:21]([CH3:23])=[N:20][N:19]=1)(=O)C.C[O-].[Na+].O.Cl>CO>[OH:4][C:5]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[S:8](=[O:15])(=[O:16])[N:7]([CH3:17])[C:6]=1[C:18]1[O:22][C:21]([CH3:23])=[N:20][N:19]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 10942334Sodium MethoxideHCID 13936581HCID 13936581, compound

Product 1

HCID 135838385HCID 135838385, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of product (b) (2.218 g) in methanol (20 ml) was added 28% sodium methoxide (1.28 ml). After stirring at room temperature for 30 minutes, the solvent was stripped off and water (30 ml) was added. With vigorous stirring the pH was adjusted to ca. 1.5 with 6N HCl and the resulting solid granulated for 1 hour, filtered off, washed with water, and dried in vacuo to give compound (c), 1.903 g, 98% yield.

Workup

  1. stirringWith vigorous stirring the pH
  2. waitthe resulting solid granulated for 1 hour
  3. filtrationfiltered off
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-f48101b188bd47d796926b7fdeb23bd5
Source dataset
uspto-grants-1987_09
Patent number
US04694080

Reaction notes

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